Utf1^tm1.1Pedr
Targeted Allele Detail

Summary

• Symbol: Utf1^tm1.1Pedr
• Name: undifferentiated embryonic cell transcription factor 1; targeted mutation 1.1, Peter Droge
• MGI ID: MGI:6193763
• Synonyms: Utf1-tomato
• Gene: Utf1 Location: Chr7:139523769-139525025 bp, + strand Genetic Position: Chr7, 84.91 cM, cytoband F5
• Alliance: Utf1^tm1.1Pedr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255683
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence for the first 173 amino-acids (containing the conserved DNA-binding domain) was replaced with a tdTomato fluorescent marker cassette. A loxP site, an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 1. The neo cassette was removed through subsequent cre-mediated recombination. This creates a knockout reporter allele, with the reporter gene expressed from the promoter of the targeted gene. (J:255683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Utf1 Mutation: 19 strains or lines available

References

• Original: J:255683 Bao Q, et al., Utf1 contributes to intergenerational epigenetic inheritance of pluripotency. Sci Rep. 2017 Nov 6;7(1):14612
• All: 1 reference(s)