Myd88^tm1.1Mmul
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1.1Mmul
• Name: myeloid differentiation primary response gene 88; targeted mutation 1.1 Mathias Muller
• MGI ID: MGI:6193650
• Synonyms: Myd88^{tm1(eGFP)Mmul}
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1.1Mmul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247029
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Exons 2 to 5 were flanked by loxP sites. A neomycin selection cassette flanked by FRT sites was inserted just after in intron 5. An eGFP gene was inserted at the beginning of exon 6. The neomycin cassette was removed upon Flpe expression by transient vector transfection in ES cells. (J:247029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 51 strains or lines available

References

• Original: J:247029 Agoro R, et al., IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 Nov;46(11):2531-2541
• All: 2 reference(s)