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Cib2tm1.1Aela
Targeted Allele Detail
Summary
Symbol: Cib2tm1.1Aela
Name: calcium and integrin binding family member 2; targeted mutation 1.1, Aziz El-Amraoui
MGI ID: MGI:6192642
Synonyms: CIB2-
Gene: Cib2  Location: Chr9:54452078-54467502 bp, - strand  Genetic Position: Chr9, 29.7 cM
Alliance: Cib2tm1.1Aela page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262464
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4, which is common to all isoforms and is predicted to encode the EF-hand domain region, was flanked by loxP sites. Cre-mediated recombination deleted exon 4. (J:262464)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cib2 Mutation:  14 strains or lines available
References
Original:  J:262464 Michel V, et al., CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO Mol Med. 2017 Dec;9(12):1711-1731
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory