Cib2^tm1.1Aela
Targeted Allele Detail

Summary

• Symbol: Cib2^tm1.1Aela
• Name: calcium and integrin binding family member 2; targeted mutation 1.1, Aziz El-Amraoui
• MGI ID: MGI:6192642
• Synonyms: CIB2^-
• Gene: Cib2 Location: Chr9:54452078-54467502 bp, - strand Genetic Position: Chr9, 29.7 cM
• Alliance: Cib2^tm1.1Aela page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262464
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, which is common to all isoforms and is predicted to encode the EF-hand domain region, was flanked by loxP sites. Cre-mediated recombination deleted exon 4. (J:262464)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cib2 Mutation: 15 strains or lines available

References

• Original: J:262464 Michel V, et al., CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO Mol Med. 2017 Dec;9(12):1711-1731
• All: 1 reference(s)