Mutyh^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Mutyh^tm1.1Lrsn
• Name: mutY DNA glycosylase; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:6192527
• Synonyms: Mutyh dMTS
• Gene: Mutyh Location: Chr4:116664920-116676637 bp, + strand Genetic Position: Chr4, 53.34 cM, cytoband C7
• Alliance: Mutyh^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a modified exon 3 lacking the mitochondrial targeting sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 3. (J:263644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mutyh Mutation: 34 strains or lines available

References

• Original: J:263644 Kauppila JHK, et al., Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res. 2018 Jul 27;46(13):6642-6669
• All: 1 reference(s)