Ogg1^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Ogg1^tm1.1Lrsn
• Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:6192526
• Synonyms: Ogg1 dMTS
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a modified exon 1 lacking the mitochondrial targeting sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 1. (J:263644)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 21 strains or lines available

References

• Original: J:263644 Kauppila JHK, et al., Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res. 2018 Jul 27;46(13):6642-6669
• All: 1 reference(s)