Nr1i2^{tm4.1(NR1I2)Arte}
Targeted Allele Detail

Summary

• Symbol: Nr1i2^{tm4.1(NR1I2)Arte}
• Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 4.1, TaconicArtemis
• MGI ID: MGI:6192066
• Synonyms: huPXRi
• Gene: Nr1i2 Location: Chr16:38068711-38115211 bp, - strand Genetic Position: Chr16, 26.64 cM
• Alliance: Nr1i2^{tm4.1(NR1I2)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263525
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an attB53 site, human sequenced (fusion of exon 2 through 4, intronic and exonic sequence from intron 4 through 7, and a fusion of exons 8 and 9), TGA stop codon, FRT-flanked hygromycin resistance cassette, and attP50 site. Flp-mediated recombination removed the selection cassette. (J:263525)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1i2 Mutation: 31 strains or lines available

References

• Original: J:263525 Scheer N, et al., In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Drug Metab Dispos. 2010 Jul;38(7):1046-53
• All: 1 reference(s)