Tg(HLA-DQA1*0301,HLA-DQB1*0302)#Dma
Transgene Detail

Summary

• Symbol: Tg(HLA-DQA1*0301,HLA-DQB1*0302)#Dma
• Name: transgene insertion, Daniel M Altmann
• MGI ID: MGI:6192038
• Synonyms: HLA-DQ8
• Transgene: Tg(HLA-DQA1*0301,HLA-DQB1*0302)#Dma Location: unknown
• Alliance: Tg(HLA-DQA1*0301,HLA-DQB1*0302)#Dma page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Genomic constructs for human MHC gene alleles HLA-DQA1*0301 and HLA-DQB1*0302 were microinjected into fertilized eggs. The resulting transgenic mice express human HLA-DQ8 serotype. (J:263607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:263607 Boyton RJ, et al., Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. Int Immunol. 1998 Dec;10(12):1765-76
• All: 3 reference(s)