Plat^em2Bug
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plat^em2Bug
• Name: plasminogen activator, tissue; endonuclease-mediated mutation 2, Thomas H Bugge
• MGI ID: MGI:6191718
• Gene: Plat Location: Chr8:23247743-23272860 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Plat^em2Bug page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: ZFN-targeting introduced mutations into the signal peptide-encoding exon 2 that removes 11 bp and introduces a frame shift mutation after Pro17 and premature stop signal. (J:263529)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plat Mutation: 61 strains or lines available

References

• Original: J:263529 Szabo R, et al., Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains. J Thromb Haemost. 2016 Aug;14(8):1618-28
• All: 1 reference(s)