Tg(CMV-PTGS1/PTGIS)#Khru
Transgene Detail

Summary

• Symbol: Tg(CMV-PTGS1/PTGIS)#Khru
• Name: transgene insertion, Ke-He Ruan
• MGI ID: MGI:6191668
• Synonyms: CP-Tg
• Transgene: Tg(CMV-PTGS1/PTGIS)#Khru Location: unknown
• Alliance: Tg(CMV-PTGS1/PTGIS)#Khru page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-PTGS1/PTGIS)#Khru expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGIS (5740)

  Ptgis

  (MGI:1097156)

  Expresses a chimeric protein of two human enzymes connected by a linker

  human

  PTGS1 (5742)

  Ptgs1

  (MGI:97797)

  Expresses a chimeric protein of two human enzymes connected by a linker

• Mutation details: The transgene contains the following elements: the CMV promoter, coding sequence for human prostaglandin-endoperoxide synthase 1, sequence for a 10 amino-acid transmembrane linker derived from human rhodopsin, prostaglandin I2 synthase coding sequence and PGH (porcine growth hormone) pA signal. The construct was microinjected into fertilized oocytes. The promoter drives ubiquitous expression of the chimeric protein. (J:260161)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:260161 Ling QL, et al., Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage. Sci Rep. 2018 Jan 26;8(1):1653
• All: 1 reference(s)