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Transgene Detail
Symbol: Tg(CMV-PTGS1/PTGIS)#Khru
Name: transgene insertion, Ke-He Ruan
MGI ID: MGI:6191668
Synonyms: CP-Tg
Transgene: Tg(CMV-PTGS1/PTGIS)#Khru  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(CMV-PTGS1/PTGIS)#Khru expresses 2 genes
Mutation detailsThe transgene contains the following elements: the CMV promoter, coding sequence for human prostaglandin-endoperoxide synthase 1, sequence for a 10 amino-acid transmembrane linker derived from human rhodopsin, prostaglandin I2 synthase coding sequence and PGH (porcine growth hormone) pA signal. The construct was microinjected into fertilized oocytes. The promoter drives ubiquitous expression of the chimeric protein. (J:260161)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:260161 Ling QL, et al., Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage. Sci Rep. 2018 Jan 26;8(1):1653
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory