Ncf1^tm1Tbph
Targeted Allele Detail

Summary

• Symbol: Ncf1^tm1Tbph
• Name: neutrophil cytosolic factor 1; targeted mutation 1, University of Turku, Department of Physiology
• MGI ID: MGI:6191621
• Synonyms: Ncf1^tm2Utu, TN2
• Gene: Ncf1 Location: Chr5:134248907-134258479 bp, - strand Genetic Position: Chr5, 74.47 cM
• Alliance: Ncf1^tm1Tbph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245008
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exons 1 and 2 with an FRT site, LoxP6 site, neomycin resistance cassette, EGFP reporter gene, IRES sequence, Ncf1 coding sequence in reverse orientation, LoxP71 site and FRT site. (J:245008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncf1 Mutation: 38 strains or lines available

References

• Original: J:245008 Sareila O, et al., Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. PLoS One. 2015;10(11):e0141974
• All: 1 reference(s)