Cdk2^tm3.1Kald
Targeted Allele Detail

Summary

• Symbol: Cdk2^tm3.1Kald
• Name: cyclin dependent kinase 2; targeted mutation 3.1, Philipp Kaldis
• MGI ID: MGI:6189554
• Synonyms: Cdk2^D145N
• Gene: Cdk2 Location: Chr10:128533808-128540900 bp, - strand Genetic Position: Chr10, 77.13 cM, cytoband D3
• Alliance: Cdk2^tm3.1Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245061
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 4 was replaced with a modified exon in which nucleotide substitution (A to G) results in the amino acid substitution of asparagine for aspartic acid at position 145 (D145N). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:245061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk2 Mutation: 16 strains or lines available

References

• Original: J:245061 Chauhan S, et al., Cdk2 catalytic activity is essential for meiotic cell division in vivo. Biochem J. 2016 Sep 15;473(18):2783-98
• All: 2 reference(s)