Vcp^tm2.1Ccrs
Targeted Allele Detail

Summary

• Symbol: Vcp^tm2.1Ccrs
• Name: valosin containing protein; targeted mutation 2.1, Christoph S Clemen and Rolf Schroder
• MGI ID: MGI:6189550
• Synonyms: Vcp^{tm2(R155C)Ccrs}
• Gene: Vcp Location: Chr4:42979964-43000507 bp, - strand Genetic Position: Chr4, 22.95 cM
• Alliance: Vcp^tm2.1Ccrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263736
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The triplet CGG in exon was replaced by a TGT resulting in the replacement of an arginine with a cysteine at position 155 (R155C) and a floxed neo cassette was inserted in intron 4. Cre mediated recombination removed the neo cassette. The remaining loxP site is located further upstream than in mice carrying Vcp ^tm1.1Ccrs to avoid the splicing issue present in this allele. (J:263736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcp Mutation: 52 strains or lines available

References

• Original: J:263736 Clemen C, VCP mouse model. MGI Direct Data Submission. 2018
• All: 4 reference(s)