Ryr2^tm6.1Amks
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm6.1Amks
• Name: ryanodine receptor 2, cardiac; targeted mutation 6.1, Andrew R Marks
• MGI ID: MGI:6189515
• Synonyms: RyR2-S2814A
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm6.1Amks page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:263461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 57 was replaced with one in which nucleotide substitutions (TCT to GCA) result in the amino acid substitution of alanine for serine at position 2814 (S2814A). A neomycin resistance cassette was removed from the final allele via Cre-mediated recombination. (J:263461)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 330 strains or lines available

References

• Original: J:263461 Kushnir A, et al., Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10274-9
• All: 1 reference(s)