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Itsn2tm1Kure
Targeted Allele Detail
Nomenclature
Symbol: Itsn2tm1Kure
Name: intersectin 2; targeted mutation 1, Shigeo Kure
MGI ID: MGI:6188888
Synonyms: Itsn2L-
Gene: Itsn2  Location: Chr12:4642792-4763952 bp, + strand  Genetic Position: Chr12, 2.09 cM, cytoband A1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262845
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsExon 31 was replaced with a modified exon containing an SV40 polyadenylation sequence and a recombinase recognition site flanked neomycin resistance cassette. This allele does not produce the long isoform. (J:262845)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itsn2 Mutation:  69 strains or lines available
References
Original:  J:262845 Ashraf S, et al., Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. Nat Commun. 2018 May 17;9(1):1960
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory