Foxn1^tm2.1Cbln
Targeted Allele Detail

Summary

• Symbol: Foxn1^tm2.1Cbln
• Name: forkhead box N1; targeted mutation 2.1, C. Clare Blackburn
• MGI ID: MGI:6188874
• Synonyms: Foxn1^G
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^tm2.1Cbln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249091
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A LoxP site-flanked cassette containing an EGFP cDNA, an IRES element, the cDNA encoding puromycin resistance and a transcriptional stop sequence, was knocked into intron 1b of the gene by homologous recombination in ES cells generating a revertible functionally null allele, (J:249091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 104 strains or lines available

References

• Original: J:249091 O'Neill KE, et al., Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. PLoS One. 2016;11(3):e0151666
• All: 3 reference(s)