Kat5^tm1Scli
Targeted Allele Detail

Summary

• Symbol: Kat5^tm1Scli
• Name: K(lysine) acetyltransferase 5; targeted mutation 1, Sheng-Cai Lin
• MGI ID: MGI:6188647
• Synonyms: Tip60-S86A, Tip60^SA
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm1Scli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262920
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A T to G mutation in exon 5 results in the amino acid substitution of alanine for serine at position 86 (S86A). An FRT-flanked neomycin resistance cassette was inserted into intron 6. (J:262920)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 28 strains or lines available

References

• Original: J:262920 Li TY, et al., Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018 May 15;9(1):1916
• All: 3 reference(s)