Casp1tm1.1Mlkf
Targeted Allele Detail
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Symbol: |
Casp1tm1.1Mlkf |
Name: |
caspase 1; targeted mutation 1.1, Mohamed Lamkanfi |
MGI ID: |
MGI:6188616 |
Gene: |
Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
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Alliance: |
Casp1tm1.1Mlkf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:263129
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
(C57BL/6J x 129)F1
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The targeting construct introduced into exon 3 an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site and loxP site. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the reporter and selection cassettes and left exons 4 and 5 floxed.
(J:263129)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Casp1 Mutation: |
41 strains or lines available
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Original: |
J:263129 Van Gorp H, et al., Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14384-14389 |
All: |
2 reference(s) |
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