Casp1^tm1.1Mlkf
Targeted Allele Detail

Summary

• Symbol: Casp1^tm1.1Mlkf
• Name: caspase 1; targeted mutation 1.1, Mohamed Lamkanfi
• MGI ID: MGI:6188616
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^tm1.1Mlkf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263129
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6J x 129)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 3 an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site and loxP site. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the reporter and selection cassettes and left exons 4 and 5 floxed. (J:263129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:263129 Van Gorp H, et al., Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14384-14389
• All: 4 reference(s)