Oxtr^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Oxtr^tm1Dgen
• Name: oxytocin receptor; targeted mutation 1, Deltagen
• MGI ID: MGI:6187919
• Synonyms: OTR KO
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262922
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neo cassette was inserted into the open reading frame replacing 725 bp of protein coding sequence. Homologous recombination was confirmed by PCR. Absence of mRNA was confirmed by on brain tissue by reta-time PCR. (J:262922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 46 strains or lines available

References

• Original: J:262922 Matsushita H, et al., Oxytocin mediates the antidepressant effects of mating behavior in male mice. Neurosci Res. 2010 Oct;68(2):151-3
• All: 3 reference(s)