Ces1g^tm1Reli
Targeted Allele Detail

Summary

• Symbol: Ces1g^tm1Reli
• Name: carboxylesterase 1G; targeted mutation 1, Richard Lehner
• MGI ID: MGI:6164718
• Synonyms: Ces1/Es-x^-
• Gene: Ces1g Location: Chr8:94028997-94063837 bp, - strand Genetic Position: Chr8, 45.29 cM
• Alliance: Ces1g^tm1Reli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262803
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 5 was replaced with a neomycin selection cassette. This resulted in the removal of the catalytic Ser221 in the encoded protein. Immunoblot analysis confirmed the absence of protein expression in the liver and small intestine of homozygous mutant mice. (J:262803)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ces1g Mutation: 45 strains or lines available

References

• Original: J:262803 Quiroga AD, et al., Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. Hepatology. 2012 Dec;56(6):2188-98
• All: 3 reference(s)