Clcnkb^tm1Doel
Targeted Allele Detail

Summary

• Symbol: Clcnkb^tm1Doel
• Name: chloride channel, voltage-sensitive Kb; targeted mutation 1, Dominique Eladari
• MGI ID: MGI:6164672
• Gene: Clcnkb Location: Chr4:141131664-141143325 bp, - strand Genetic Position: Chr4, 74.02 cM, cytoband E1
• Alliance: Clcnkb^tm1Doel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259639
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 5-10 were flanked with loxP sites. A loxP site was inserted into intron 4, and an frt-flanked neomycin selection cassette follwed by a second loxP site was inserted into intron 10. (J:259639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcnkb Mutation: 25 strains or lines available

References

• Original: J:259639 Hennings JC, et al., The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron. J Am Soc Nephrol. 2017 Jan;28(1):209-217
• All: 1 reference(s)