Hoxa^tm2.1Ssp
Targeted Allele Detail

Summary

• Symbol: Hoxa^tm2.1Ssp
• Name: homeobox A cluster; targeted mutation 2.1, S Steven Potter
• MGI ID: MGI:6164646
• Synonyms: Hoxa9,10-
• Gene: Hoxa Location: unknown Genetic Position: Chr6, cytoband B3-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262635
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Hoxa^tm2.1Ssp involves 2 genes/genome features (Hoxa9, Hoxa10) View all
• Mutation details: The BAC RP23-20F21 was used to sequentially targeted Hoxa9, and Hoxa10. In each gene a kan/neo cassette flanked by once only lox66 and lox71 was introduced into exon 1. This insertion introduced a small deletion/frameshift. In Hoxa9 the selection cassette was removed by cre mediated recombination before targeting of the subsequent gene. Thus only Hoxa10 retains the selection cassette in the final targeting vector and this was removed after targeting by cre mediated recombination. (J:262635)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa Mutation: 0 strains or lines available

Notes

es cells = SE2

References

• Original: J:262635 Drake KA, et al., Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney. Sci Rep. 2018 Apr 20;8(1):6306
• All: 2 reference(s)