Ano2^{Tn(pb-Act-RFP)1.090616068-HRAZhu}
Transposon induced Allele Detail

Summary

• Symbol: Ano2^{Tn(pb-Act-RFP)1.090616068-HRAZhu}
• Name: anoctamin 2; transposon insertion 1.090616068-HRA, Yuan Zhuang
• MGI ID: MGI:6164620
• Synonyms: Ano2^Pb
• Gene: Ano2 Location: Chr6:125667382-126017089 bp, + strand Genetic Position: Chr6, 59.58 cM
• Alliance: Ano2^{Tn(pb-Act-RFP)1.090616068-HRAZhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Null/knockout)
• Mutation: Insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. This line contains a transposon inserted into intron 14. Immunohistochemical analysis confirmed the absence of protein in olfactory cilia from homozygous mice. (J:123680, J:262494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano2 Mutation: 57 strains or lines available

References

• Original: J:262494 Li RC, et al., Ca(2+)-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5570-5575
• All: 3 reference(s)