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Endonuclease-mediated Allele Detail
Symbol: Card14em5Lutzy
Name: caspase recruitment domain family, member 14; endonuclease-mediated mutation 5, Cathy Lutz
MGI ID: MGI:6164594
Synonyms: Card14deltaE138
Gene: Card14  Location: Chr11:119307768-119345375 bp, + strand  Genetic Position: Chr11, 83.36 cM
Strain of Origin:  C57BL/6J
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Intragenic deletion
Mutation detailsCRISPR/cas9 endonuclease mediated genome editing was used to introduce a deletion of a GAG codon from exon 6 that results in the deletion of the glutamic acid (E) at position 138. Card14em5Lutzy and Card14em9Lutzy were generated from two different founders, both carry the same mutation. (J:262723)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Card14 Mutation:  21 strains or lines available
Original:  J:262723 Mellett M, et al., CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo. J Invest Dermatol. 2018 Apr 21;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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