Plcg2^em3Adiuj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcg2^em3Adiuj
• Name: phospholipase C, gamma 2; endonuclease-mediated mutation 3, MODEL-AD Center
• MGI ID: MGI:6164497
• Synonyms: Plcg2^M28L
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^em3Adiuj page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The allele was generated by injecting cas9 nuclease and a single guide RNA designed to introduce a M28L point mutation. (J:341528)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:341528 Oblak AL, et al., Plcg2(M28L) Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice. Front Aging Neurosci. 2022;14:886575
• All: 1 reference(s)