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Endonuclease-mediated Allele Detail
Symbol: Abca7em2Adiuj
Name: ATP-binding cassette, sub-family A (ABC1), member 7; endonuclease-mediated mutation 2, MODEL-AD Center
MGI ID: MGI:6164020
Gene: Abca7  Location: Chr10:79996494-80015572 bp, + strand  Genetic Position: Chr10, 39.72 cM
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsCRISPR/Cas9 genome editing methodology is used to introduce an alanine to glycine at position 1527 in exon 33. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca7 Mutation:  46 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory