Calcr^tm1.1Sfuk
Targeted Allele Detail

Summary

• Symbol: Calcr^tm1.1Sfuk
• Name: calcitonin receptor; targeted mutation 1, So-ichiro Fukada
• MGI ID: MGI:6164014
• Synonyms: Calcr^flox
• Gene: Calcr Location: Chr6:3685680-3764714 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Calcr^tm1.1Sfuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260355
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 3714493 of Chromosome 6 upstream of exon 6 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 6 at position 3714493. Exon 6 is thus flanked by loxP sites. Flp mediated recombination removed the lacZ and neo cassettes. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:260355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcr Mutation: 59 strains or lines available

References

• Original: J:260355 Yamaguchi M, et al., Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche. Cell Rep. 2015 Oct 13;13(2):302-14
• All: 6 reference(s)