Tet2^tm1.2Iaai
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1.2Iaai
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1.2, Iannis Aifantis
• MGI ID: MGI:6164009
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1.2Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174053
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An FRT- and loxP-flanked neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Recombinase-mediated recombination removed the neo cassette and exon 3. (J:174053)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 783 strains or lines available

References

• Original: J:174053 Moran-Crusio K, et al., Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011 Jul 12;20(1):11-24
• All: 6 reference(s)