Mirc22^tm1.1Mtm
Targeted Allele Detail

Summary

• Symbol: Mirc22^tm1.1Mtm
• Name: microRNA cluster 22, including Mir23b through Mir24-1; targeted mutation 1.1, Micheal McManus
• MGI ID: MGI:6163636
• Synonyms: Mirc22^f
• Gene: Mirc22 Location: Chr13:63448298-63449089 bp Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258947
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites flank the cluster containing Mir23b, Mir27b and Mir24-1. A frt-flanked neomycin selection cassette was removed via Flp-mediated recombination. (J:258947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc22 Mutation: 3 strains or lines available

References

• Original: J:258947 Pua HH, et al., MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19;44(4):821-32
• All: 2 reference(s)