Tg(Wap-EIF4E)3Vipo
Transgene Detail

Summary

• Symbol: Tg(Wap-EIF4E)3Vipo
• Name: transgene insertion 3, Vitaly Polunovsky
• MGI ID: MGI:6162679
• Synonyms: HA-eIF4E
• Transgene: Tg(Wap-EIF4E)3Vipo Location: unknown
• Alliance: Tg(Wap-EIF4E)3Vipo page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Wap-EIF4E)3Vipo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EIF4E (1977)

  Eif4e

  (MGI:95305)

  rat Wap promoter

• Mutation details: The mammary gland specific rat promotor drives expression of the human gene. To distinguish the exogenous transgene-encoded peptide from the endogenous peptide, the human peptide was engineered with three C-terminal hemagglutinin (HA) epitope tags. Three transgenic lines were established, with line number 3 chosen for further experiments. (J:218834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:218834 Avdulov S, et al., eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells. Cancer Res. 2015 Feb 15;75(4):687-97
• All: 1 reference(s)