Setd2^tm2.1Smoc
Targeted Allele Detail

Summary

• Symbol: Setd2^tm2.1Smoc
• Name: SET domain containing 2; targeted mutation 2.1, Shanghai Model Organisms Center
• MGI ID: MGI:6162482
• Synonyms: Setd2^fl
• Gene: Setd2 Location: Chr9:110361368-110447703 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^tm2.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6 and a FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette, leaving exons 6-7 floxed. (J:247783)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:247783 Yuan H, et al., Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest. 2017 Sep 01;127(9):3375-3391
• All: 13 reference(s)