Bmi1^tm1Rxi
Targeted Allele Detail

Summary

• Symbol: Bmi1^tm1Rxi
• Name: Bmi1 proto-oncogene, polycomb ring finger; targeted mutation 1, Rongwen Xi
• MGI ID: MGI:6162460
• Synonyms: Bmi1^F, Bmi1^loxP
• Gene: Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
• Alliance: Bmi1^tm1Rxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked neomycin resistance cassette followed by a second loxP site were inserted downstream of exon 8. (J:262366)

Tumor Data

List all tumor models in MMHCdb carrying Bmi1^tm1Rxi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmi1 Mutation: 33 strains or lines available

References

• Original: J:262366 Liu X, et al., BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Dec;153(6):1607-1620
• All: 4 reference(s)