Rnh1^tm1Rall
Targeted Allele Detail

Summary

• Symbol: Rnh1^tm1Rall
• Name: ribonuclease/angiogenin inhibitor 1; targeted mutation 1, Ramanjaneyulu Allam
• MGI ID: MGI:6162065
• Synonyms: Rnh1^-
• Gene: Rnh1 Location: Chr7:140740239-140752764 bp, - strand Genetic Position: Chr7, 86.44 cM
• Alliance: Rnh1^tm1Rall page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP- and FRT-flanked neomycin cassette replaced 6.89 kb of the gene, including exons 2-10. qRT-PCR analysis confirmed the absence of mRNA expression in the yolk sac of E9.5 homozygous mutant embryos. (J:261784)

Expression

In Mice Carrying this Mutation:	24 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnh1 Mutation: 23 strains or lines available

References

• Original: J:261784 Chennupati V, et al., Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018 Apr 2;128(4):1597-1614
• All: 1 reference(s)