Slit3^tm1.1Jmko
Targeted Allele Detail

Summary

• Symbol: Slit3^tm1.1Jmko
• Name: slit guidance ligand 3; targeted mutation 1.1, Jung-Min Koh
• MGI ID: MGI:6162061
• Synonyms: Slit3^fl
• Gene: Slit3 Location: Chr11:35012283-35599334 bp, + strand Genetic Position: Chr11, 20.29 cM, cytoband A5
• Alliance: Slit3^tm1.1Jmko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261788
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 7 approximately 500 bp 5' of exon 8, and a second loxP site together with the FRT-PGKneo-FRT cassette was inserted in intron 8 approximately 600 bp 3' of exon 8. Flp-mediated recombination removed the PGKneo cassette, leaving exon 8 floxed. (J:261788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slit3 Mutation: 81 strains or lines available

References

• Original: J:261788 Kim BJ, et al., Osteoclast-secreted SLIT3 coordinates bone resorption and formation. J Clin Invest. 2018 Apr 2;128(4):1429-1441
• All: 1 reference(s)