Cdkl5^tm1.1Teta
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.1Teta
• Name: cyclin dependent kinase like 5; targeted mutation 1.1, Teruyuki Tanaka
• MGI ID: MGI:6160922
• Synonyms: Cdkl5^-
• Gene: Cdkl5 Location: ChrX:159567241-159777673 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.1Teta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259068
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into exon 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 2. Exon 2 was deleted through subsequent cre-mediated recombination, creating a null allele. (J:259068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 23 strains or lines available

References

• Original: J:259068 Okuda K, et al., CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility. Neurobiol Dis. 2017 Oct;106:158-170
• All: 2 reference(s)