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Acantm1c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Acantm1c(EUCOMM)Hmgu
Name: aggrecan; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:6160877
Synonyms: Acan-loxP
Gene: Acan  Location: Chr7:78703231-78764847 bp, + strand  Genetic Position: Chr7, 44.88 cM
Alliance: Acantm1c(EUCOMM)Hmgu page
IMPC: Acan gene page
Mutation
origin
Mutant Cell Lines:  HEPD0602_5_F12, HEPD0602_5_G11
Germline Transmission:  Earliest citation of germline transmission: J:267250
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsFlp-mediated recombination of the parental Acantm1a(EUCOMM)Hmgu allele excised the splice acceptor-lacZ reporter sequence and the neomycin selection cassette from the third intron, leaving the critical exon 4 flanked by loxP sites. Exposure to Cre recombinase will delete exon 4, resulting in a null mutation. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:267250)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acan Mutation:  77 strains or lines available
References
Original:  J:267250 Rowlands D, et al., Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity. J Neurosci. 2018 Nov 21;38(47):10102-10113
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory