Ppbp^tm1Tgen
Targeted Allele Detail

Summary

• Symbol: Ppbp^tm1Tgen
• Name: pro-platelet basic protein; targeted mutation 1, TransGenic
• MGI ID: MGI:6160872
• Synonyms: Ppbp^dE2E3
• Gene: Ppbp Location: Chr5:90916377-90917922 bp, + strand Genetic Position: Chr5, 44.78 cM
• Alliance: Ppbp^tm1Tgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262080
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site and gene trap cassette upstream of exon 2. A neomycin resistance cassette was inserted between exon 2 and 3. An additional loxP site was introduced downstream of exon 3. (J:262080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppbp Mutation: 8 strains or lines available

References

• Original: J:262080 Tsuru M, et al., Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification. PLoS One. 2018;13(5):e0196204
• All: 1 reference(s)