Tg(hs218-cre/ERT2,-GFP)1Jlr
Transgene Detail

Summary

• Symbol: Tg(hs218-cre/ERT2,-GFP)1Jlr
• Name: transgene insertion 1, John Rubenstein
• MGI ID: MGI:6160851
• Synonyms: 218-CreER-IRES-GFP, Tg(FOXP2-cre/ERT2,-GFP)1Jlr
• Transgene: Tg(hs218-cre/ERT2,-GFP)1Jlr Location: unknown
• Alliance: Tg(hs218-cre/ERT2,-GFP)1Jlr page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(hs218-cre/ERT2,-GFP)1Jlr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  human	hs218

• Mutation details: This transgene contains the human enhancer element hs218, which resides within the FOXP2 gene, followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:214335)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	hs218 (human) Summary of all recombinase alleles driven by hs218.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:214335 Pattabiraman K, et al., Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003
• All: 1 reference(s)