Dlx2^tm3.1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx2^tm3.1Jlr
• Name: distal-less homeobox 2; targeted mutation 3.1, JL Rubenstein
• MGI ID: MGI:6160436
• Synonyms: Dlx2^f, Dlx2 floxed
• Gene: Dlx2 Location: Chr2:71373752-71377095 bp, - strand Genetic Position: Chr2, 42.65 cM
• Alliance: Dlx2^tm3.1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260050
• Parent Cell Line: D2 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites have been inserted into introns 1 and 3. A single FRT site in the 3' untranslated region (UTR), just 5' of the Pgk-neo cassette, marks the former site of a neomycin selection cassette that has been deleted by flp recombinase. Crossing mice bearing this allele with Cre recombinase-expressing mice will delete exons 2 and 3, which contain the entire homeodomain. (J:94077, J:260050)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx2 Mutation: 25 strains or lines available

References

• Original: J:260050 Pla R, et al., Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis. Cereb Cortex. 2017 Sep 28;:1-19
• All: 2 reference(s)