Creb1^tm1.1Rst
Targeted Allele Detail

Summary

• Symbol: Creb1^tm1.1Rst
• Name: cAMP responsive element binding protein 1; targeted mutation 1.1, Randal S Tibbetts
• MGI ID: MGI:6160078
• Synonyms: CREB^S111A
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm1.1Rst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246737
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 5 was replaced with one in which the sequence was altered to generate the amino acid substitution of alanine for serine at position 111 (S111A). Recombination removed the neomycin resistance cassette inserted upstream of the modified exon 5. (J:246737)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 59 strains or lines available

References

• Original: J:246737 Kim SH, et al., Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism. Nucleic Acids Res. 2016 Nov 16;44(20):9667-9680
• All: 1 reference(s)