Myo6^rsv
Spontaneous Allele Detail

Summary

• Symbol: Myo6^rsv
• Name: myosin VI; Rinshoken shaker/waltzer
• MGI ID: MGI:6160069
• Synonyms: rsv
• Gene: Myo6 Location: Chr9:80072313-80219011 bp, + strand Genetic Position: Chr9, 43.98 cM
• Alliance: Myo6^rsv page

Mutation origin

• Strain of Origin: C57BL/6Slc

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Undefined
• Mutation details: RT-PCR and immunohistochemical analysis indicates greatly reduced mRNA expression and absence of protein expression in homozygous mice. However, no mutations in Myo6 exon sequence, exon-intron boundaries or promoter region are detected. An alternative splice variant of Myo6 is found in both rsv mice and wild-type mice. The non-recombinant region spans from D9Mit74 to D9Nok18. (J:261136)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo6 Mutation: 90 strains or lines available

References

• Original: J:261136 Mochizuki E, et al., Phenotypic and expression analysis of a novel spontaneous myosin VI null mutant mouse. Exp Anim. 2010;59(1):57-71
• All: 2 reference(s)