Sumo1^em1Dwcl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sumo1^em1Dwcl
• Name: small ubiquitin-like modifier 1; endonuclease-mediated mutation 1, David Wan-Cheng Li
• MGI ID: MGI:6159938
• Gene: Sumo1 Location: Chr1:59678593-59709993 bp, - strand Genetic Position: Chr1, 30.32 cM, cytoband C2-C3
• Alliance: Sumo1^em1Dwcl page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 409 bp deletion in exon 2 and intron 2, including 11 bp of exon 2, was created by CRISPR/Cas9 meditated recombination. Immunoblot analysis confirmed the absence of protein expression in retinal extracts from homozygous mice. (J:261820)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sumo1 Mutation: 67 strains or lines available

References

• Original: J:261820 Gong L, et al., Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3987-E3995
• All: 1 reference(s)