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Adra1btm1.1Pcs
Targeted Allele Detail
Summary
Symbol: Adra1btm1.1Pcs
Name: adrenergic receptor, alpha 1b; targeted mutation 1.1, Paul C Simpson
MGI ID: MGI:6159917
Gene: Adra1b  Location: Chr11:43665433-43792037 bp, - strand  Genetic Position: Chr11, 25.81 cM
Alliance: Adra1btm1.1Pcs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261969
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced with a human PLAP reporter gene and an FRT flanked neo resistance cassette via homologous recombination. Flp mediated recombination removed the neo cassette. Expression of the reporter gene is under control of all endogenous regulatory elements. (J:261969)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adra1b Mutation:  19 strains or lines available
References
Original:  J:261969 Myagmar BE, et al., Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31;120(7):1103-1115
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory