Adra1b^tm1.1Pcs
Targeted Allele Detail

Summary

• Symbol: Adra1b^tm1.1Pcs
• Name: adrenergic receptor, alpha 1b; targeted mutation 1.1, Paul C Simpson
• MGI ID: MGI:6159917
• Gene: Adra1b Location: Chr11:43665433-43792037 bp, - strand Genetic Position: Chr11, 25.81 cM
• Alliance: Adra1b^tm1.1Pcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261969
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a human PLAP reporter gene and an FRT flanked neo resistance cassette via homologous recombination. Flp mediated recombination removed the neo cassette. Expression of the reporter gene is under control of all endogenous regulatory elements. (J:261969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra1b Mutation: 18 strains or lines available

References

• Original: J:261969 Myagmar BE, et al., Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31;120(7):1103-1115
• All: 1 reference(s)