Fto^em1Fmas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fto^em1Fmas
• Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Frances M Ashcroft
• MGI ID: MGI:6159866
• Synonyms: FTO-R313A
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^em1Fmas page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A CGT -> GCT (R313A) mutation was created in exon 5 via CRISPR/Cas9 meidated recombination. This mutation is designed be orthologus to a human mutation that eliminates demethylase activity. (J:262081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:262081 Sachse G, et al., FTO demethylase activity is essential for normal bone growth and bone mineralization in mice. Biochim Biophys Acta. 2018 Mar;1864(3):843-850
• All: 1 reference(s)