Pten^tm1.1Jcad
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.1Jcad
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Juan Cadinanos
• MGI ID: MGI:6159664
• Synonyms: Pten^SBm2
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.1Jcad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244930
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Undefined
• Mutation details: A loxP site, inverted sleeping beauty repeat and lox2272 were inserted upstream of exon 5 and a lox 2272 site, inverted sleeping beauty repeat and FRT flanked kanamycin and puromycin resistance cassette were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the resistance cassette. (J:244930)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1.1Jcad

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 81 strains or lines available

References

• Original: J:244930 de la Rosa J, et al., A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nat Genet. 2017 May;49(5):730-741
• All: 2 reference(s)