Cd300a^tm2.1Shib
Targeted Allele Detail

Summary

• Symbol: Cd300a^tm2.1Shib
• Name: CD300A molecule; targeted mutation 2.1, Akira Shibuya
• MGI ID: MGI:6159333
• Synonyms: Cd300a^fl
• Gene: Cd300a Location: Chr11:114780006-114792772 bp, + strand Genetic Position: Chr11, 80.54 cM
• Alliance: Cd300a^tm2.1Shib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a FRT-flanked PGK-gb2-neo cassette in opposite coding direction followed by a second loxP site were inserted downstream of exon 1. Flp-mediated recombination removed the neomycin selection cassette, leaving exon 1 floxed. (J:246647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd300a Mutation: 22 strains or lines available

References

• Original: J:246647 Udayanga KG, et al., Immunoreceptor CD300a on mast cells and dendritic cells regulates neutrophil recruitment in a murine model of sepsis. Int Immunol. 2016 Dec;28(12):611-615
• All: 3 reference(s)