Rbck1^tm1.2Hwal
Targeted Allele Detail

Summary

• Symbol: Rbck1^tm1.2Hwal
• Name: RanBP-type and C3HC4-type zinc finger containing 1; targeted mutation 1.2, Henning Walczak
• MGI ID: MGI:6159166
• Gene: Rbck1 Location: Chr2:152158254-152174573 bp, - strand Genetic Position: Chr2, 74.83 cM
• Alliance: Rbck1^tm1.2Hwal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were floxed and an FRT flanked hygro cassette was inserted in intron 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the hygro cassette. (J:261640)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbck1 Mutation: 43 strains or lines available

References

• Original: J:261640 Peltzer N, et al., LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018 May;557(7703):112-117
• All: 1 reference(s)