Efemp2^tm2Chu
Targeted Allele Detail

Summary

• Symbol: Efemp2^tm2Chu
• Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 2, Mon-Li Chu
• MGI ID: MGI:6158964
• Gene: Efemp2 Location: Chr19:5523982-5532545 bp, + strand Genetic Position: Chr19, 4.33 cM, cytoband A
• Alliance: Efemp2^tm2Chu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261872
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region encompassing parts of exons 2 and 4 and all of exon 3 was replaced with an EYFP gene and pgk-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in fibroblasts from homozygous mice. (J:261872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efemp2 Mutation: 26 strains or lines available

References

• Original: J:261872 Markova DZ, et al., Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice. Cell Tissue Res. 2016 Jun;364(3):637-46
• All: 2 reference(s)