Fhod3^tm2.1Hsum
Targeted Allele Detail

Summary

• Symbol: Fhod3^tm2.1Hsum
• Name: formin homology 2 domain containing 3; targeted mutation 2.1, Hideki Sumimoto
• MGI ID: MGI:6158460
• Synonyms: Fhod3^flox
• Gene: Fhod3 Location: Chr18:24841680-25266558 bp, + strand Genetic Position: Chr18, 13.18 cM
• Alliance: Fhod3^tm2.1Hsum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256068
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an frt-flanked neomycin selection cassette was inserted 5' to exon 18, and a single loxP site was inserted 3' to exon 18. FLP-mediated recombination removed the neomycin selection cassette, leaving loxP sites that flank exon 18. (J:256068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fhod3 Mutation: 93 strains or lines available

References

• Original: J:256068 Ushijima T, et al., The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. J Biol Chem. 2018 Jan 5;293(1):148-162
• All: 2 reference(s)