Lpcat3^tm1.1Igl
Targeted Allele Detail

Summary

• Symbol: Lpcat3^tm1.1Igl
• Name: lysophosphatidylcholine acyltransferase 3; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:6158452
• Synonyms: Lpcat3-Flox
• Gene: Lpcat3 Location: Chr6:124639887-124681142 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Lpcat3^tm1.1Igl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232731
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an frt-flanked neomycin selection cassette was inserted between exons 2 and 3, and a second loxP site was inserted between exons 6 and 7. The neomycin selection cassette was removed via Flp-mediated recombination. (J:232731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpcat3 Mutation: 25 strains or lines available

References

• Original: J:232731 Kabir I, et al., Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism. J Biol Chem. 2016 Apr 1;291(14):7651-60
• All: 3 reference(s)