H2-T^em1.1Dwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-T^em1.1Dwl
• Name: histocompatibility 2, T region; endonuclease-mediated mutation 1.1, David Wiest
• MGI ID: MGI:6158395
• Synonyms: H2t^-
• Gene: H2-T Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• H2-T^em1.1Dwl involves 11 genes/genome features (H2-T24, H2-T23, H2-T22 ...) View all
• Mutation details: ZFN-targeting inserted a loxP sites 5' of H2-T24 and 3' of H2-T3. Cre-mediated recombination removed the interviewing sequence. (J:261393)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-T Mutation: 2 strains or lines available

References

• Original: J:261393 Fahl SP, et al., Role of a selecting ligand in shaping the murine gammadelta-TCR repertoire. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1889-1894
• All: 1 reference(s)